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A man's hand was cut off in a brutal machete attack, according to reports.
Police said the victim suffered life-changing injuries from the attack in Kirkdale, Liverpool.
Officers were called to the scene at about 5.55pm after reports a man in his 20s had been attacked, the Liverpool Echo reports.
Children were seen playing football as officers scoured the streets for evidence.
A police cordon was put up while officers searched the area.
Neighbours claimed they were unable to leave their homes due to the large police presence, and called the incident "scary".
They said the man's had was cut off during the attack.
One woman said: "There is lots of police here. A man had his hand chopped off with a machete.
"More and more police and forensics keep arriving."
Another added: "Someone got rammed off the road and someone's hand got chopped off."
Police said they believe the attack was "targeted and isolated".
Detectives are working to establish a motive.
Chief Inspector Colin Rooney said: "The fact that such a violent incident has taken place in broad daylight on a busy road is particularly shocking.
"At this early stage we think it was a targeted and isolated incident, but need to understand precisely what happened and why.
"If you did see or hear anything, or were passing by Chirkdale Street or Delamore Street and have CCTV or dashcam, please come forward in confidence and we will take action to identify those responsible.
"Knife crime has no place in our communities and by coming together, we can remove criminals and their dangerous weapons from the streets."
Officers were seen going door-to-door at the scene.
The force said the victim was taken to hospital after the attack.
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